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Moreover, several lncRNAs exhibit very precise expression patterns in different tissues (Amaral and Mattick, 2008; Mercer et al, 2008).
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Finally, this study underlines the precise expression pattern in GC of the FST gene that plays an important role in female fertility by regulating activin and members of the BMP subfamily [ 67].
Most notably, in developmental genes, multiple binding sites of different TFs are often located close to each other in genomes, forming so called cis-regulatory modules (CRMs), and work together to generate precise expression patterns [2].
The RNA sequencing results are therefore supported by the RNA in situ results reported by Chung et al. (2009), but the differences in the expression patterns suggest that care must be exercised when inferring precise expression patterns from either of the two data sets.
Here, we report the identification of a large number of novel cis-elements at mammalian Hox clusters that can help in regulating their precise expression pattern.
It is possible that B. mori CCEs expressed in the male testis have similar functions although the precise expression pattern might be different.
The present study, in which we used Gsdma KO mice, allowed us to observe the precise expression pattern of Gsdma3 without influence of Gsdma.
The precise analysis of the expression patterns in specific tissues, at different developmental stages and under different stimulations of individual isoforms will facilitate the dissection of their specific functions.
The close proximity of these mountains in Figure 2 was indicative of the similarity of their expression patterns (see Figure 5), yet ExprAlign cleanly resolved even these subtly different expression patterns in precise agreement with the sequence alignments.
Schaner, M.E. et al. Gene expression patterns in ovarian carcinomas.
Whitney, A.R. et al. Individuality and variation in gene expression patterns in human blood.
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