Upon photo-illumination, ATLANS introduced a precise double-stranded break 12 bp downstream the TFO binding sequence and down-regulated the target gene in HeLa cell system.
With advancements in using such editing tools as zinc finger nucleases (ZFNs), meganucleases, and transcription activator-like effector nucleases (TALENs), etc., scientists are able to design DNA-binding proteins, which can make precise double-strand breaks (DSBs) at the target DNA.
"Sorry, sorry," I mumbled, overcome, as I was led into a precise double-turn that literally took me off my shoes and into his chest.
To illustrate how the method works we start with a high tolerance and short word-length ((epsilon=10^{-2}), (L_{mathrm{w}=40mboxx{ bits})), which is less precise than double-precision.
Arsenal loanee Joel Campbell's precise shot doubled the lead and the visitors only came to life late on.
Lazar Markovic's precise finish doubled the lead, but the Reds were thankful for Yann Kermorgant's glaring miss.
The Proton-Induced SpAllation (PISA) experiment performed at the internal beam facility of the COSY storage ring in Jülich, Germany, which is aimed at the precise measurement of double differential cross-sections over a broad range of energies and angles for spallation reactions induced by protons of 200 2500 MeV energy in various targets, is presented.
And yet the rhythm of this opening spat, the music of the dialogue as staged by Hal Brooks, is as precise as a double-act comedy routine.
Data concerning the induction efficacy of CZP differed among the double-blind PRECiSE 1 trial (35%), the double-blind phase II trial (45%), and the open-label phase of the PRECiSE 2 trial (64%) (Schreiber et al. 2005a, 2007a; Sandborn et al. 2007a).
The NEMO-3 experiment performed precise measurement of the double beta decay and searched for the neutrinoless double beta decay on seven isotopes, among which 100Mo and 82Se were the dominant ones.
These are exquisitely precise articulations of a double ghosting: more than a half-century of repurposing obligated by embargo, and inevitable evanescence in a recapitalized future where such sites will either be exalted into next-gen Mar-a-Lagos or dance to the tune of the demolition ball.
