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These findings support precise disruptions of limbic-cortical integrity in schizophrenia.
These findings support precise disruptions of limbic-cortical integrity in schizophrenia and disruption of these structural networks may contribute towards the neural basis underlying the syndrome of schizophrenia and clinical symptomatology.
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Precise timing-disruption experiments were conducted by using stimuli modeled after those in [45].
Using the ARAi system, the gene expression was up-regulated over 800-fold with highly inducing stringency, and the target specificity of ClosTron was greatly improved to support precise gene disruption in C. cellulolyticum.
Concerning differences in the precise nature of disruptions, of the two PTPN3 mutant mice that were generated in our laboratory, we established by Western blotting that expression of PTPN3 protein was extinguished.
Although qualitative traits can be more difficult to engineer using disruption, precise base editing may allow an efficient path to rationally improve qualitative traits if protein function can be accurately modelled.
For PTPN3, discrepancies might again be explained by differences in background strain or the precise nature of genetic disruptions.
It is possible that this discrepancy can be explained in terms of differences in genetic background or the precise nature of genetic disruptions in PTPN3 mutant strains.
Hence, delicate handling of tissue with instruments, judicious elevation of tissue to minimize vascular disruption, and precise alignment of tissue planes are all important elements of technique.
The purpose of designing an optimal and fault tolerant communication network is to achieve a precise performance without any disruption at a minimal cost.
Resolution of these possibilities will require identification of protein targets of srn-mediated fucosylation and exploration of their role in CNS synaptic connectivity, and/or analyses of mutants with more precise spatial and temporal disruption of Notch-Delta signaling than are currently available.
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