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Despite years of research, the precise determinants of coronavirus replication and pathogenesis remain unidentified.
The precise determinants and clinical significance of these changes warrants further investigation.
To dissect the precise determinants of NGL specificity, we introduced point mutations in the NetrinG-binding surface of NGL1, which transplanted the corresponding NGL2 surface.
While a major role for the CC domain was proposed, the precise determinants favoring sGC heterodimerization remain ambiguous and warrant further studies.
On the one hand, the precise determinants of the activation of each known Akt isoform specifically remain poorly understood [ 6, 16– 18, 55, 56].
The precise determinants of this effect remain to some extent unclear, since distance to the town, access to health facilities, lack of a cash economy and differential availability of food are all highly confounded within the urban-rural paradigm.
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We strongly recommend future researchers use uniform definitions of determinants, disease, and disease progression; it would enable more precise determination of possible risk factors for knee OA progression through meta-analyses.
Consequently, the precise molecular determinants responsible for melanoma progression are yet to be delineated.
Instead of charge-based interactions, which will not exclusively occur at the biofilm, one should screen for specific targeting agents, directed against precise bacterial determinants, while considering that higher specificity is often accompanied with lower affinity.
Establishment of more precise prognostic determinants using molecular biology techniques is warranted to make the best use of these options.
These results show that complex traits, such as the ability of a stimulus to reverse drug-induced hypnosis, may have precise genetic determinants.
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