Despite years of research, the precise determinants of coronavirus replication and pathogenesis remain unidentified.
However, an understanding of the precise determinants of this control, including the role of other cell-cycle regulatory activities, has not been clearly defined.
The precise determinants and clinical significance of these changes warrants further investigation.
To dissect the precise determinants of NGL specificity, we introduced point mutations in the NetrinG-binding surface of NGL1, which transplanted the corresponding NGL2 surface.
While a major role for the CC domain was proposed, the precise determinants favoring sGC heterodimerization remain ambiguous and warrant further studies.
On the one hand, the precise determinants of the activation of each known Akt isoform specifically remain poorly understood [ 6, 16– 18, 55, 56].
The precise determinants of this effect remain to some extent unclear, since distance to the town, access to health facilities, lack of a cash economy and differential availability of food are all highly confounded within the urban-rural paradigm.
In a similar way, our results may indicate a modest improvement in HPA axis regulation in the intervention group but further research is needed to confirm this and delineate the precise determinants of HPA axis modulation.
Additional research is needed to further investigate the precise determinants, outcomes, and nature of physician-older patient communication about depression, but there is growing evidence that the methods of communication described in this review are important steps in improving the health care experiences and quality of life of older patients.
We strongly recommend future researchers use uniform definitions of determinants, disease, and disease progression; it would enable more precise determination of possible risk factors for knee OA progression through meta-analyses.
In a large retrospective series of resected Japanese patients, it was observed that the number of lymph nodes involved was a more precise prognostic determinant than their location and could be considered for the nodal stage classification as is done in other organs [62].
