LncRNAs can exhibit subcellular localization in precise compartments and, although they are expressed in lower amount with respect to mRNA [ 4], these transcripts are even more cell-type specific and strictly associated with developmental stages [ 5– 7].
Of all 58 tumors, our new method determined that 57 could be assigned to precise PPS compartments.
Although the model can identify the presence of poorly drained compartments, precise estimation of reservoir pressure in poorly drained compartments requires geological data, production data and estimates of bottom-hole flowing pressure.
Establishing and maintaining the distinct molecular composition of axonal and dendritic compartments requires precise control over the trafficking of the proteins that make up these cellular domains.
Since the targets of many therapeutic agents are localized in subcellular compartments, modulation of nanoparticle cell interactions for efficient cellular uptake through the plasma membrane and the development of nanomedicines for precise delivery to subcellular compartments remain formidable challenges.
The precise balance of Ca2+ compartments might be important in specifying final cardiomyocyte differentiation.
These functional changes could alter the ability of tubular cells in maintaining compositionally distinct fluid-filled compartments with precise electrolyte concentrations.
Although the precise identification of these intracellular compartments warrants a refined analysis by electron microscopy, Nef co-localizes with these receptors in perinuclear compartments that might be, at least in parts, identical to the RE-like compartment of Lck accumulation.
Further characterization of the localized STATIP1 pools could reveal its precise role in these cellular compartments.
A major advantage of genetically encoded sensors is the ability for relatively easy and precise targeting to specific subcellular compartments.
