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In our model the combined deletion of both Lkb1 and Pten in the mouse bladder drastically activates mTOR pathway and this precise activation serves as a signal for EMT program execution (Fig. 6).
It is involved in non-painful cool sensation and triggered by diverse chemical and physical stimuli whose precise activation mechanism is still unknown.
The ability to use light as a stimulation tool provides, in principle, a non-invasive method for the temporally and spatially precise activation of any neuron or any part of a neuron.
According to the comparison made between experimental and predicted kinetic parameters of thermal degradation process calculated from Friedman and Kissinger methods, the proposed prediction effort could effectively contribute to the estimation of precise activation energy (Ea) and reaction order (n) values with least amount of experimental work and most accuracy.
Such data illustrate the fact that future developments of efficient MEA stimulation devices will require precise activation of small groups of neurons, so that each electrode of an array will act as an independent "stimulation pixel", directly influencing cells in its close vicinity, and not those located in the vicinity of other electrodes.
Normal metazoan development occurs through the correct activation of different signalling pathways leading in turn to the temporally precise activation of transcriptional networks [ 1].
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Averaging over the brain correlates of variable speech stimuli, for example, will blur and possibly remove early focal and short-lived brain activity, therefore making it impossible to study precise early activation time courses (Pulvermüller and Shtyrov 2006).
Development of chronic epileptogenesis by a precise focal activation of the target brain site is readily achieved with no mortality and very little morbidity.
Another impasse was the lack of a stimulation technique allowing for precise neuron activation that would not interfere with the freezing process.
DOI: http://dx.doi.org/10.7554/eLife.03043.002 Skilled performance in music, speech, or sports often involves long sequences of movements, which demand a precise sequential activation of different muscles in time.
Sox9 is a key transcription factor that is essential for chondrocyte differentiation and chondrocyte-specific gene expressions; however, the precise transcriptional activation mechanism of Sox9 is not fully understood.
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