Transgenic mice with mutations in sod1 are a well-characterized animal model of human ALS and have precipitous, age-related loss of motor neurons (4– 6).
Moreover, unlike the gray matter, which showed a more gradual shrinkage over time, the decline in white matter was most precipitous between the ages of 70 and 80.
We found progressive declines in the proportion of naïve CD4 T cells with age, a precipitous drop in γδ T cells after the second year of life and an increase in acute phase protein levels amongst geriatric sheep.
Since this phenomenon of precipitous changes in the age structure of smallpox mortality appears in a local study, we need to establish that it is not a product of some local peculiarity in the care of smallpox sufferers.
The application of Cox proportional hazards studies have also confirmed that having a non-PN tumour was the most statistically significant factor in predicting precipitous short survival over age by two orders of magnitude.
They showed 927 girls for every 1,000 boys under age 6, a precipitous decline from 962 girls 20 years earlier.
Results indicated that deficits in health and social resources were largely responsible for the precipitous decline in SOC after age 70.
Demographers generally agree that China should be, if anything, encouraging more births to avoid a precipitous decline in the working-age population.
A composite graph depicting the expression trends in the three specimens across all age groups shows the precipitous decline in plasma, but gradual decline in PBMCs from 4 months on, and the brain-specific rise at 28 days followed by the decline at 12 months old.
A likely interpretation of these disappointing results is that the heavy burden of infectious diseases, and the associated chronic environmental gastroenteropathy that affects most children in developing countries and is the major cause of the precipitous fall-off in height-for-age in infancy, simply overwhelms attempts at intervention (31).
When the rain lifts, however, these precipitous escarpments -- the legacy of Ice Age glacial deposits -- are exactly where a curious visitor will want to go.
