All species demonstrate a loss of asymmetry in the developing limb/fin bud preceding the development of unpatterned polydactyly (mouse and chicken) and a loss of PTCH1 expression in areas expressing Hedgehog ligands.
Studies from India reporting patients with TB preceding the development of sarcoidosis or concurrent presence of both diseases have been described [3, 4].
An elevation of liver and spleen elasticity was demonstrated with MR elastography in an animal model of portal hypertension, preceding the development of liver fibrosis [16].
Increased NR2B subunit levels led also to a gradual down-regulation of cerebellar NR2A levels, preceding the development of motor impairment in adult animals.
To characterize the pathological changes preceding the development of drusen-associated atrophy in eyes with age-related macular degeneration (AMD) using spectral-domain optical coherence tomography (SD-OCT).
Screening for precursor changes in the mucosal linings preceding the development of invasive tumors and for accurate prediction of risk of malignant transformation, may be propitious opportunities, which are as yet difficult.
These symptoms are also present in patients with mild cognitive impairment (MCI) and can even constitute the first manifestations of a neurodegenerative process, preceding the development of cognitive symptoms.
The high internal friction angles derived for the Shimanto and Boso siltstone samples studied here show that the response to pre-failure loading is similar to that of hard rocks (see, e.g., discussion in Savage et al. 1997) and describes a mechanical state preceding the development of coalescing microcracks to produce failure.
The area of low pressure preceding the development of Bertha produced rough surf and rip currents along the Florida coastline.
Interestingly, decreased levels of urine nuclease activity has been found in lupus-prone B/W mice, preceding the development of renal disease manifestation [25].
Findings of expression in different cell types of the kidney provided preliminary evidence that PVT1 may influence metabolic dysregulation in this tissue preceding the development of renal failure in diabetes.
