The achievement gaps we see in elementary school and beyond begin before children enter kindergarten the quality of child care and educational settings in the years preceding matter.
Neuropathological studies also indicated pathological alterations in white matter preceding grey matter atrophy [ 23, 33].
Given that white matter degeneration may be an early marker of disease, preceding grey matter atrophy, understanding the mechanisms and risk factors that may lead to white matter loss could help to identify those at high risk and to intervene earlier in the pathogenic process.
Given that white matter change may be an early marker of disease, preceding grey matter atrophy, understanding the mechanisms and risk factors that may lead to white matter damage could provide a novel mechanism by which to identify those at high risk, allowing us to intervene earlier in the pathogenic process.
Although the identified coefficients from the present healthy sample are only minor to medium in magnitude, it is to note that two traits might be only rudimentarily related in the healthy brain, but might show stronger links in the pathologically altered brain (e.g. hypoperfusion preceding gray matter atrophy).
The fact that white matter volume loss was more extensive than grey matter volume loss raises the possibility that white matter loss may actually precede grey matter loss, as opposed to white matter loss occurring via Wallerian degeneration.
In other words, mind precedes matter.
Although once thought to occur secondary to grey matter degeneration, recent studies demonstrated that some white matter changes in AD may occur independently of and precede grey matter atrophy [ 3, 4].
The 71-year-old former minister, who once reputedly had the power to crown state premiers, sat quietly in the back of the crowded courtroom with his hands clasped as the magistrate dealt with the routine assaults, affrays and robberies that preceded his matter.
It appears that normalization is not restricted to speech but that the nature of the preceding sounds does matter.
