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Patients were counted as tegaserod initiators if a first known dispensing was preceded by at least six months in the database, and comparators similarly needed at least six months of preceding database enrollment for eligibility.
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Primary studies were eligible for inclusion only if they had been published before June 2004 and if the entry date of a study in a database preceded the date of the literature search of any systematic review analysed.
New versions of the databases are currently scheduled to be released on a monthly basis, incorporating all new submissions to the database over the preceding month.
Only 14.2% of patients did not have updated information in the 5 years preceding the closing of the database for analysis.
Among the 2054 patients, 540 patients (26.3%) had their last follow-up visit within the year preceding the closing of the database, 1042 patients (50.7%) within the previous 2 years and 1337 patients (65.1%) within the previous 3 years.
More precisely, the optimal predecessor is a non-overlapping chain preceding the fragment in both database and query sequence that leads to the maximal combined score considering the gap cost penalty between them.
For each follow-up visit, we expected a CD4 count test to be done if there was no CD4 result entered in the database in the preceding 160 days.
A second approach using HMM models and searching the general NCBI non-redundant (nr) peptide and an invertebrate subset of the NCBI nucleotide and EST (est_others) databases corroborated the preceding results.
aCategorisation as given in the BVL database on plant protection products [[20]]; this categorisation of products is largely but not entirely consistent with the categorisation of active substances used in the EU pesticide database [[19]] (see preceding tables).
Perform cluster analysis using the k-means method (Hartingan and Wong 1979) on the database obtained at the preceding step (Fig. 5a).
The RMQ reports the element with maximal priority within a given range that involves only non-overlapping chains preceding the current fragment in both database and query sequence.
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