This result is not without precedent: previous studies have identified intragenic epistasis (da Silva et al. 2010), and in one case, conformational changes in the protein products were directly linked to epistasis between allelic variants within the relevant gene (Ortlund et al. 2007).
This situation is not without precedent, as biochemical and structural studies have shown that nuclear localization of the Stat family members and SREBP-2 similarly requires dimerization [23], [24].
Recent studies have provided precedent for epigenetic silencing across an entire chromosome band in colorectal cancer (Frigola et al, 2006); however, this does not appear to be the case for the S100 gene cluster in medulloblastoma.
Indeed, other studies have confirmed there is a real historical precedent for such perception [ 8, 31] even if practices have changed in recent times.
Both breast and endometrial cancers have been examined as precedent conditions in case-control studies of PD, and no association has been found; 13, 14 however, many studies have reported overall reduced cancer rates or mortality in PD patients.
Previous studies have identified genetic differences among animals in relation to BRDC susceptibility, thereby providing ample support and precedent for this hypothesis and investigation [ 16– 16].
Architectural studies have established that these buildings first were constructed at the end of the 15th century without previous local precedent.
Because a precedent study, which had found significantly higher CD4+NKG2D+ T cells in RA vs. controls, had used another anti-NKG2D mAb, i.e. 1D11 (BD PharMingen) (vs. the above used ON72 clone, Beckman Coulter), we also tested this antibody.
Such an ERP component, called mismatch negativity (MMN), has been robustly observed in many precedent studies (for reviews, see ref. [14], [15]).
