Thus, significant increases in differentiation-induced transcriptional activation on day 2 preceded elevations in Tfam mRNA and protein expression evident by day 4.
Furthermore, concurrent temporal analysis of H1-T6SS expression and cell lysis in TLFM sequences indicated that P. aeruginosa lysis precedes elevation of ClpV1-GFP expression and the initiation of B. thai cell death.
In the acute kidney injury (AKI) setting, FGF-23 elevation may precede creatinine elevation and phosphate metabolism impairment [ 91].
Interestingly, when BOLD MRI was recorded in a different tumor model, a brief, transient signal dip preceded the elevation of BOLD contrast.
The increase in serum bile acids preceded the elevation in cholesterol levels (compare Figures 4A and 4D).
Importantly, a marked amount of diabetes was preceded by elevation in one of the glycemic markers only, with limited overlap among the three.
In addition, the onset of clinical disease was preceded by elevations in rectal temperature, and biphasic rectal temperature profiles were observed in some animals (3/4 infected pigs remaining from dpi 5 onwards; 5/8 in-contacts), a clinical feature often observed during influenza infections [11] [13].
Since the two receptors, A1R and A2AR, have opposing biological effects, and A1R domination precedes the elevation of A2AR, we sought to examine whether A1R activation would be one of the factors that trigger the anti-inflammatory phase, and whether this action is mediated by upregulation of the A2AR.
Induction of NGAL after kidney injury precedes the elevation of classical markers for kidney damage [ 27, 28], e.g. serum creatinine, urinary N-acetyl glucosamidase and β2-microglobulin levels.
In experimental CRI, reduced vasodilatation via Ca2+-activated K+-channels (BKCa), observed in isolated mesenteric arterial branches, may precede the elevation of blood pressure (BP) [ 15, 16].
