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Both have been referred to as precursors because they precede the development of ESF.
Given that glucose intolerance and insulin resistance precede the development of overt diabetes, these factors would be associated with CAD.
Knuckle pads are caused by focal fibrous thickening dorsally at the proximal interphalangeal (PIP) or metacarpophalangeal (MCP) joint, and may precede the development of palmar fibromatosis.
Recent studies have reported that elevated SUA precedes the development of MetS in humans[42], suggesting that it might precede the development of leptin resistance.
In type 1 diabetes, increases in sodium lithium countertransport (Na Li CT), kidney volume (KV), and albumin excretion rate (AER) may precede the development of persistent microalbuminuria.
The time context points to diabetes preceding changes in HRV, while changes in HRV precede the development of atherosclerosis and IHD.
The proposed staging resulted from the mounting evidence of biomarker data that suggested AD begins before the development of clinical symptoms and that emerging technology could identify brain changes that precede the development of symptoms.
Metabolic changes precede the development of type 2 diabetes by years or even decades.
These changes precede the development of whole body insulin resistance and glucose intolerance.
Kalliomaki et al. showed that differences in the intestinal microbiota may precede the development of an overweight phenotype [25].
Lower mtDNA copy number in peripheral blood mononuclear cells was shown to precede the development of diabetes [26].
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