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Paradoxically, amongst BCG responders there was a correlation between pre-existing response and subsequent response to BCG.
However, in this latter case Tregs must control two distinct effector immune responses: a pre-existing response towards self-antigens and a de novo response induced by the newly transplanted allogeneic cells.
The present studies suggest that humans may also be able to use nonverbal status cues that simulate the appearance of body size to capitalize on pre-existing response tendencies to those appearance cues.
Group II (seven patients) showed lymphocyte proliferation in response to the vaccine but had no pre-existing response to 105AD7.
A further six patients had a pre-existing response to CD55 that was not boosted by vaccination with 105AD7.
Group III (13 patients) showed a pre-existing response to 105AD7, which was subsequently boosted by the vaccine.
Similar(53)
As adults, the cattle with pre-existing responses to environmental mycobacteria were much less responsive to vaccination than were naïve adult cattle [ 33].
However, pre-existing responses due to natural exposure, nature of carrier protein and nature of the polysaccharide itself could be important in determining responses to each serotype.
These data could help address whether learning increases reliability of pre-existing responses already tied to specific time points (i.e., reinforces a pre-existing sequence), vs reconfigures activity by shifting peaks in time or generating new responses.
PHiD-CV would therefore be expected to boost pre-existing responses against diphtheria toxoid and tetanus toxoid, components of diphtheria, tetanus and acellular pertussis immunization (DTaP) administered to children in the first year of life.
Notably, the vaccination schedule did not alter significantly the proportions of participants that had detectable memory B cells against tetanus toxoid and diphtheria toxoid, probably because the participants had high pre-existing responses.
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