Proof of pluripotency by teratoma formation, in its current form, probably need not remain a required assay for disease modeling studies that use pre-established derivation methods, as much more quantitative methods exist to assay iPSC quality and differentiation.
The behavioural data obtained will be compared (1) to the 'best behaviour rules' in the OR, pre-established using a Delphi method and (2) to surrogates of the infectious risk represented by microbiological air counts, particle counts, and a bacteriological sample of the wound at closing.
The methodological soundness of each article was based on a quality evaluation method that followed pre-established characteristics that were modified from other methods reported previously [24, 25].
In this study we have investigated an integrated immunotherapy method against pre-established metastases in three kinds of advanced cancer models including B16 melanoma, 4T1 breast tumor, and Hca hepatoma.
However, such methods often require pre-established fingerprint databases, which are costly to collect, and looking-up such large-scale databases is also computationally intensive.
A systematic review of randomized controlled trials, with meta-analysis where possible, was performed following a pre-established protocol and in accordance with the method described in the Cochrane Handbook for Systematic Reviews of Interventions [ 16].
The method used needs to be pre-established and consistently followed throughout an analysis.
As opposed to these methods, in the approach described here we do not use a set of pre-established families to estimate similarity between organisms, but rather develop a method to select the families which are consistently found only in one of the two types of organisms, pathogens and non-pathogens, and show that this is more powerful than using global similarity.
As none of the three DLT-evaluable patients experienced a DLT at this dose, DL1 was expanded in part B for confirmation of the RP2D as pre-established in the protocol according to the modified toxicity probability method.
To address this point, this paper (i) uses a pre-established detailed identification of road cuts (Naulin et al., 2013) and (ii) applies a well-known traffic attribution method to existing and freely available census datasets.
