The TouchPad interacts with the Palm Pre, specifically the Pre 3. Pre interaction is quite cool but quite limited.
Potentially, such SNPs may represent sites at which risk alleles have major impacts on TF/uDBP-PRE interaction, with important downstream consequences that predispose to psoriasis, or genetically-related autoimmune diseases [96].
An alternative model, however, is that an accumulation of risk alleles at non-coding loci, each with minor effects on TF/uDBP-PRE interaction, has an aggregate effect promoting susceptibility in those individuals with the greatest cumulative risk allele burden (Figure 8B).
We classified all pre-mRNA sites involved in the establishment of lncRNA-pre-mRNA interactions according to their location on pre-mRNA and found that 14% (720) of interactions occur in potential AS regions.
We detected 5208 potential lncRNA-pre-mRNA interactions between 1221 lncRNAs and pre-mRNA for 1761 genes (Supplementary Table S4).
Moreover, previous studies indicated that the two proteins, Imp3 and Imp4, are essential to mediate the U3-pre-rRNA interactions and greatly increase the stability of the unstable U3-pre-rRNA duplexes (Gerczei and Correll 2004; Gerczei et al. 2009).
These results clearly indicate PRE-specific interactions with the genomic environment at each site, and suggest that sequences within each PRE may be interacting with a selected set of enhancers and/or repressors.
The LAST alignment tool was used to calculate the potential lncRNA-mRNA and lncRNA-pre-mRNA interactions.
