Of these, three treatments were carried out at each of the 5, 10, 20, and 40 J cm−1 settings; a further patient was later also treated at 40 J cm−1 as it was an earlier patient in this group in which it was not possible to assess the extent of PDT necrosis due to pre-existing necrosis.
Many linkages were pre-existing.
Is there a pre existing depression here anyway?
Our new proposed method of determining recurrent or residual glioma using magnetically label CTLs may suffer from artifacts due to pre-existing hemorrhage, necrosis and heterogeneity of vascular changes.
This leads to suppose that granulomatous tissue observed at 3 months in AFT grafts could represent focal area of pre-existing fat reabsorption due to the intensive necrosis observed 7 days after transplantation, as described for lipophagic necrosis in later stages of ischemic necrosis [ 26].
To avoid patients with pre-existing vascular issues (such as existing avascular necrosis of the femoral head), patients were limited to those with a pre-operative diagnosis of osteoarthritis.
Early recognition of TMA in our patient was impeded as the initial biopsy did not report TMA as the cause of brain necrosis, mild pancytopenia was pre-existing and clear signs of thrombotic microangiopathy with hemolysis were missing until major cerebral damage had occurred.
Because drugs such as anti-cancer or anti-tumor necrosis factor-α may exacerbate pre-existing IP [ 18, 19], there was concern that administration of PC-SOD would induce AE of IP.
Calcification within neoplasms may have several aetiologies, including tumour engulfment of adjacent pre-existing adjacent calcification, dystrophic calcification within areas of tumour necrosis or as primary tumour calcification.
A possible mechanism can be the subacute, excessive growth of the pre-existing adenoma, which outgrows its blood supply with eventual ischaemic necrosis followed by haemorrhage [2, 35].
Another patient in the 300 mg group with pre-existing intermittent mild transaminase elevations and polyarthritis developed submassive hepatic necrosis with hepatic failure during cycle 3 while receiving a reduced fedratinib dose of 200 mg.
