Exact(3)
Our results also show that VEGF induced vasodilatation only occurs in ET-1 pre contracted vessels.
The results also show that bevacizumab can inhibit the VEGF induced vasodilatations in pre contracted retinal arterioles.
With the presence of bevacizumab in the bath, VEGF still produced a concentration dependent dilatation (p < 0.001) in ET-1 pre contracted vessels.
Similar(57)
In experiments on rat middle meningeal arteries, pre-contracted with PGF2α, similar tendencies were seen.
All the synthesized compounds showed significant vasodilation properties using isolated thoracic aortic rings of rats pre-contracted with norepinephrine hydrochloride standard technique.
Next, the segment was pre-contracted with 10-6 M prostaglandin F2α (PGF2α) to achieve a stable tension for the duration of the experiment.
The relaxing effects of KTCGY, KTCGYKTCGY, TCGYTCGY, KRIHF, and captopril on PE (0.3 μM) pre-contracted endothelium-intact or endothelium-denuded aortic rings were examined.
The new chemical entities showed significant vasodilation properties using isolated thoracic aortic rings of rats pre-contracted with norepinephrine hydrochloride standard technique.
Eupatorin caused the relaxation of aortic rings pre-contracted with phenylephrine with and without endothelium (pD2=6.66±0.13, EMAX=99.72±6.39%; pD2=6.10±0.22, EMAX=65.78±8.01%), and also the relaxation of endothelium-intact aortic rings pre-contracted with potassium chloride (pD2=6.20±0.30, EMAX=71.89±12.25%).
Fig. 2 Effect of 0,1μM and 1μM telcagepant on CGRP-induced reduction in [Ca2+]i (a) and tension (b) of rat MCAs pre-contracted with 0,1 μM U46619.
The functional effect of these potential structurally novel BK-openers on vascular contractile function were studied in vitro, using isolated rat aortic rings pre-contracted with KCl 20 mM.
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