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Blood samples were collected from study participants at baseline before the first vaccination, before the second vaccination, and at 3 weeks and 6 months after the second vaccination (pre-booster).
The participants who had been previously vaccinated against yellow fever all showed seroprotection after booster vaccination, irrespective of their pre-booster VN capacity, implying that circulating neutralizing antibodies did not interfere with the induction of a booster response.
After PHiD-CV booster vaccination, the anti-protein D antibody GMC increased 10.9-fold from pre-booster GMC.
The mice were bled once (pre-booster), and then they were given booster injections in the same manner.
Pre-booster, between 34.6 and 45.5% were seroprotected against Hib (≥ 0.15 μg/ml) and between 63.6 and 65.8% were seropositive for anti-BPT antibodies (≥ 15 EL.U/ml).
The booster SCRs (using Month 6 pre-booster titer as the pre-vaccination titer), against the primary and booster vaccine strains were 91.0% and 94.1%, respectively (Table 2).
The pre-booster concentration of both diphtheria and tetanus antibodies correlated well with the results at the two subsequent examinations (Table 2).
All analyses were repeated with adjustment also for the pre-booster antibody concentration at age 5 (see Additional file 1, p. 13 15).
Depending on the serotype, antibody GMCs and OPA GMTs increased 6.7- to 32.6-fold and 2.8- to 402.2-fold 402.2-foldely, comparespectively-booster values.
Booster SCRs (using Month 36 pre-booster as pre-vaccination titer) were 99.5% and 98.1% against the primary and booster strains, respectively.
Geometric mean concentrations (GMCs) for anti-diphtheria and anti-tetanus at pre-booster time point were at least 0.289 IU/ml in both groups.
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