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First, there is a limit to the number of fragments that can be pragmatically tested, and the size of current fragment libraries has repeatedly been shown to be sufficient to find interesting chemotypes.
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The researchers did not pragmatically test the framework within an industry environment [36].
Although the original validation of Sepsis-3 definitions did not include patients with ICU LOS <2 days [9], we included all patients in the period described, independently of LOS, in order to pragmatically test the definitions in our ICU.
It must be pointed out that this study was a pragmatic trial and the interventions tested were what would be affordable or pragmatically possible in NHS disease surveillance programmes.
Only 1% of Indonesian women have ever been tested for HIV.Most governments are responding pragmatically.
Pragmatically, there have to be modifications of these criteria, and, because these involve departures from accepted criteria, they should then be tested and shown to be methodologically sound in a validation study that compares diagnoses obtained by the study instrument with those of one or more headache experts ("gold standard": see page 20).
(Oh, and you write tests, pragmatically. That's not in the name, but it's pretty important too).
The sample size is determined pragmatically by the need to gain sufficient experience of the intervention over a range of settings and participants and thus test feasibility on a realistic basis.
However, traditional toxicological studies on botanicals are scientifically and pragmatically challenging due to testing of complex mixtures of constituents, cost, time, and animal usage.
Minor disagreements were resolved pragmatically in the field testing, based on the feasibility of the evaluation options.
Since this is an exploratory study designed to provide information for further analytic research, sample size will be determined partly pragmatically rather than on particular hypothesis tests.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com