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The sample size of 50 cases per centre was chosen as a pragmatic size to balance the workload imposed by the study while providing a reasonable number of patients for computing completeness proportions.
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A pragmatic sample size of 20 patients was chosen for this observational study.
As for round 1, this is a pragmatic sample size given the time and resources available for the study.
For partners of pregnant teenagers, a pragmatic sample size of 150 was determined on the basis of available resources.
A minimum of eight participants from each group will be interviewed as a pragmatic sample size, given time and resources.
The pragmatic sample size of thirty patient-caregiver dyads was expected based on Phase 1 recruitment [ 6, 16] and funds available.
To undertake this descriptive study, a target of 20 patients with severe TBI was set as a pragmatic sample size to test whether temporal artery temperature performs better to predict brain temperature after TBI than tympanic membrane temperature does.
The pragmatic sample size of 120 participants for the trial was selected with reference to the general rule of thumb recommended by Lancaster et al. [ 27], taking account of the factorial design of this exploratory trial and the primary and secondary outcome measures to be investigated.
For pragmatic reasons (sample size, reasonable expected positive predictive value) and ethical considerations (mandated RHC in all patients) the DETECT algorithm is designed for application in a high-risk SSc population (inclusion criteria DLCO <60% and SSc disease duration >3 years).
A pragmatic approach to sample size calculation was taken as there were no available data to estimate an effect size.
Our sample size was pragmatic allowing recruitment in a single winter season.
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