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Very clear-cut differences in frequency and form were found across the three disciplines reflecting fundamental differences in pragmatic intention inherent in the disciplines concerned.
Additional measures to promote awareness of the intervention may be required to promote health care professionals' utilisation of the intervention and these might sometimes compromise the pragmatic intention of a trial.
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In general, radical postures disguise pragmatic intentions.
Hollande's team have stressed that his cautious and pragmatic intentions are the reverse of François Mitterrand, the last socialist president's early days in 1981 which saw an initial 18 months of high spending before being forced into a U-turn and austerity.
If the government deviates from its predecessor's orthodoxy, it will be in areas such as industrial policy, where some of Lula's appointees are keen on activism.Brazil's prospects turn on whether Lula can turn these pragmatic intentions into policy achievements.
The trial benefited from a pragmatic setting, intention-to-treat analysis, blinding of outcome assessment and a broad socioeconomic spectrum of participants.
The resultant science was a pragmatic one whose intention was not to provide a critique or to produce unconventional knowledge (Lehoux et al. 2008); a civilised science (Lehoux et al. 2008).
As the study is pragmatic in design, the planned analysis will be by intention to treat.
As appropriate to pragmatic trials an intention-to-treat approach was used as the primary analysis strategy in which all patients were analysed according to their initial group allocation.
Whereas the results of a per-protocol analysis may provide additional insights in why a treatment has (or lacks) effect in every day practice, in pragmatic trials the intention-to-treat analysis is the way to determine the overall effect.
This raises questions about how far randomised trials of complex interventions can, or, indeed, should, permit flexibility in the means of delivery of an intervention, when the aim of the study is pragmatic: ie, when the intention is to find out if the intervention would work in the uncontrolled realities of everyday lives.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com