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The diversity of the S. pastorianus genome likely originates from as many different brewing practices (differences in temperature profiles, wort compositions, strain management, etc).
If PS matching had achieved an exact or near exact match between case and comparison practices, differences in observed practice characteristics between the physicians in the treatment and comparison groups might have been negligible, making covariate adjustment for practice characteristics in a multivariate regression unnecessary.
While it is true that there will always be some variation based on local referral practices, differences in health care provision and so on, and while it is also true that CFS remains a difficult and elusive construct, even when international consensus criteria are applied, we doubt that this could explain the full range of differences in prevalence of XMRV published to date.
In addition, between types of CM practices differences are found in types of diagnoses.
Between CM practices differences were found on specific domains of complaints.
Because of the clustering of patients within areas (reflecting both country differences as well as primary care practices differences and regional differences), we took the design effect into account.
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These differences appear to be related to practice pattern differences.
There were no practice pattern differences between the two organizations.
However, it should be borne in mind that sociological and clinical practice differences may imply underlying different meanings regarding PC and end of life issues.
To account for practice differences, multilevel modelling was used with observations (at different time points) nested within participants, and participants nested within practices.
No data has surfaced linking such regional practice differences to better outcomes.
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