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Given the growing impact of scientific knowledge and discoveries on clinical practice, translational medicine was initially described as "the marriage between new discoveries in basic science and clinical practice" [5].
32 There are necessarily limits to clinical development durations, but this is only one part of the whole discovery to clinical practice translational pathway and increased time in one part of the pathway may be offset by gains elsewhere.
This project represents an interface between T3 (moving evidence-based guidelines into health practice through implementation research) and T4 (evaluation of health outcomes on real-world, population health practice) translational research and will inform this avenue of relatively under-developed research in the field to date [ 80- 82].
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International policy suggests that collaborative priority setting (CPS) between researchers and end users of research should shape the research agenda, and can increase capacity to address the research-practice translational gap.
Improving the tailoring or personalization of treatment, founded upon patient and tumour characteristics, is therefore a major objective of clinical practice and translational research.
This is an effort of general practice driven translational research that attempts to bridge analytical data with psycho-social meanings in terms of religiosity, spirituality, and components of individual's sense of coherence and well-being.
The current practice of translational biomedical research is failing its end-users, with as much as 90%% of 'highly promising basic science discoveries failing to enter routine clinical use within 20 years' [ 1].
The findings of the study also reflect the reality of industry sponsorship of much clinical investigation in gastroenterology and hepatology and highlight some of the critical gaps in the clinical research infrastructure [ 28] that may ultimately limit the expansion of evidence-based clinical practice and translational research.
The slow pace of growth of several of these leads could be attributed to regulatory protection of classical formulation, lack of standardization, quality control, mechanism-based studies, population-based normal range of biomarkers, good laboratory practices, and translational scientists engaged in conducting well-designed trials.
We must understand translation more expansively to envisage how translational practice might be broadened.
That coordination of laboratory research with clinical practice, known as translational medicine, has come to occupy a major position in oncology and has yielded important findings for cancer diagnosis and therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com