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In clinical practice, mutation analyses are performed from a tissue sample available, preferably from a recently detected and resected metastasis.
In clinical practice, mutation analyses are performed from a tissue sample available, preferably from a recently detected biopsied or resected metastasis.
Moreover, in clinical practice mutation testing is mostly performed for both genes simultaneously, and thus separation of the results is less relevant.
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In practice, background mutation loads are reduced by repeated backcrosses of plants with mutations of interest to the parent line or by marker assisted backcross selection to a different variety.
If the key changes, do (or la) shifts to a new pitch (similar to the old practice of mutation).
One discovery is expected to affect medical practice — a mutation that can cause some patients with the brain cancer to get worse instead of better if they are given a common chemotherapy.
It is quite costly in practice because mutation rates at most microsatellite loci are not large enough to be accurately estimated with a reasonable sample size.
In routine practice, KRAS mutations in codons 12 and 13 are tested, which comprise approximately 96% of the observed KRAS mutations [ 7].
Mutations generated using a fluctuation assay can, in principle, arise anywhere in the genome; however, in practice these mutations very often arise in a handful of genes known to be important in whatever selective medium was used.
In current clinical practice, gene mutations are only classified as being present or absent, ignoring the clonal complexity of cancers.
As an example of the research and evolution in lung cancer, within 10 years of the first TKI use in clinical practice, a new mutation appeared in far higher proportions in treated patients, T790, a mutation that makes them non-responsive to first and second generation TKIs [13].
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