We consider it advantageous, not disadvantageous, that the participating practices were heterogeneous (as GP practices in Germany are).
1 2 4 6 9 Furthermore, this heterogeneity increases the external validity and generalisability for daily clinical practice where heterogeneous RTP criteria are used.
Continuous flow chemistry is a rapidly developing branch in organic and drugs synthesis, whereas it is common practice in heterogeneous catalysis for base chemicals production.
However, in practice, the heterogeneous building environment will cause different indoor temperature variations, and different people may have different thermal preferences.
Extracts of natural allergen sources currently used in clinical practice are heterogeneous and their composition and content in major and minor allergens are variable.
The data about this interval in clinical practice is heterogeneous and inconclusive, however the literature estimates it to be about 60 s in monitored units.
The significance of the different findings of this is not clear; however, it does raise the question as to why practice is heterogeneous.
More recently, Sean Tunis at the Center for Medical Services (CMS) described the defining features of an effectiveness trial as comparing clinically important interventions, a diverse population of study participants representative of clinical practice, a heterogeneous practice setting also representative of clinical practice, and a broad range of clinically relevant health outcomes [ 8].
Most RCTs, however, have been conducted to assess efficacy rather than effectiveness (i.e. placebo-controlled double blinded trials rather than pragmatic trials), in specialist practice, in heterogeneous patient groups, with a short-term follow-up and using a single measuring moment.
(iii) Participating practices were heterogeneous with respect to the GPs' experience, age and gender as well as practice location.
