This condition is probably the most physically and practically challenging in regard to immobility and need for assistance (as included respondents have reported to have "heavy impairment of motor ability"), hence we may assume that the workload on the spouses has been particularly heavy.
However, this is practically challenging, since access to portal venous and hepatic venous blood is ethically justified only in persons with a clinical indication for TIPS placement.
Though practically challenging, efforts to systematically obtain postmortem brains from subjects in these trials would be of major utility for the field.
It is possible to undertake trials that include such long-term consequences but these trials are often costly and practically challenging, due to the remoteness of the effects, requiring long follow-up periods and large sample sizes.
However, a double-blind study in oncology patients would be ethically and practically challenging as it would expose them to excessive burden: subcutaneous injections of a placebo drug in patients assigned to warfarin treatment and placebo tablets with sham INR monitoring requiring multiple unnecessary blood draws in patients assigned to long-term tinzaparin treatment.
For testing programs with large item pools, implementing the VITP approach could be practically challenging, as the RT thresholds need to be identified item by item.
Planning and managing intermodal traffic demand/supply systems for special events is theoretically and practically challenging in its own right.
However, the likelihood inference for Gaussian mixtures with unrestricted covariance matrices is theoretically and practically challenging because the likelihood function is unbounded and often has multiple local maximizers.
This is in part due to the fact that the investigation of anatomical development in this age group is both technically and practically challenging [Dean et al., 2014; Raschle et al., 2012].
Weatherspoon practically challenged Wauters to spar, which resulted in a technical for the Liberty guard.
And efforts to ensure banks can be wound down safely are laudable, if practically challenging.
