From a practical perspective, antibiotics are convenient stressors because their effects can be studied with small organisms (bacteria), thereby allowing investigation of rescue dynamics with sufficient replication under well-controlled conditions in the laboratory over relatively short time windows (hours to days).
The drugsellers have considerable "practical knowledge" of antibiotics and a perception of antibiotic resistance based on practical experience.
Viberg et al. (29) subsequently report that drug-sellers have considerable practical knowledge of antibiotics.
From a practical point, the antibiotic levels in a titanium-alloy implant may be regulated by reinjection until infection is under control.
Because class 1 integron has had a major role in the spread of antibiotic resistance and has led to worldwide difficulties in controlling bacterial infection, understanding the origin of these elements is important for the practical control of antibiotic resistance and for exploring the means by which bacterial lateral gene transfer can seriously impact, and be impacted by, human activities.
Further investigation of this and similar compounds such as the structurally related 1,8-naphthyridones (which are quinolones with a nitrogen atom substituting C-8) resulted in the discovery of nalidixic acid (1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid), which was to become the first practical synthetic quinolone antibiotic (Lesher et al., 1962).
When I went to a GP for the second time in a week with mastitis, was I given practical advice, or different antibiotics, or even the number of a breastfeeding helpline?
Ribosome engineering has proven to be a practical method for increasing antibiotic production, and is extensively applied to strain improvement in antibiotic production and activation of silent genes in several prokaryotes.
As a result, the practical therapeutic use of antibiotic peptides is significantly impaired or attenuated.
Various tricks and remedies can help, though for those who repeatedly get infections, the most practical medical answer is preventative antibiotics, prescribed by a doctor and taken regularly.
