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In general, MdG is a well-tolerated and practicable regimen.
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Therefore, these results indicated that the ATG-based regimen was sufficiently practicable and comparable with other myeloablative conditioning regimens with regards to TRM, although the rates of gastrointestinal toxicity and cytomegalovirus infection were higher.
Moreover, they are not practicable in a general practice setting due to their extensiveness.
Further simplification and standardisation of regimens would make scaling up treatment more practicable, but potentially increases the risk of XDR-TB development.
As the risks of infertility (through oligospermia) were considered significant with the doses of cisplatin used in this regimen, sperm storage was offered to all patients prechemotherapy if practicable.
Non-inferiority pivotal trials require that, as far as practicable, the same techniques are used as were employed when the trials assessing the standard regimen were conducted.
As difficult as it is to conduct such trials to the level of accepted standards, we would also like to point out that comparisons or documentation of treatment regimens, although not necessarily based on a randomized study, can also be immensely useful and practicable for quickly discerning and reporting failing treatments.
This is simply not practicable.
But that is not practicable.
dosing regimen.
Do you think this is practicable?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com