However, many of these measures were abbreviated, adapted or subscales modified in order to make it practicable to collect data in such a large cohort.
The DRAGEN alignment and variant calling hardware and software has specifications which are likely to make genome sequencing practicable in many hospital laboratories, such as reducing the need for cloud computing or a large local cluster.
Although partial blockade of mutated Cav1.4 channels seems to be a possibility to modulate these channels, such an approach is not practicable in vivo because antagonist drugs such as the DHP isradipine [72] are 10- to 20-fold more potent in blocking Cav1.2 compared to Cav1.4 channels.
However, the use of an oesophageal balloon is not practicable in applications during mechanical ventilation such as noninvasive ventilation or weaning.
Because of the low frequency of obstetric admissions, it was not practicable to withhold a random validation sample, even in such a large database as this.
A certain amount of the reported data may thus not be representative, but alternative methods of gathering information in such a context are difficult, laborious and not practicable.
Because of the immediacy and high-profile nature of these issues, a workshop was held on September 30 , 2004 at the Wadsworth Center in Albany, New York, to discuss how to make such a protocol practicable in a research setting and to gain input from the scientific community.
The act requires an employer "to conduct his undertaking in such a way as to ensure, so far as is reasonably practicable, that [third parties]...are not thereby exposed to risks to their health or safety".
Moreover, they are not practicable in a general practice setting due to their extensiveness.
Mr. Cohen can avoid liability if he can establish that SAC had a system in place that "would reasonably be expected to prevent and detect, insofar as practicable, any such violation by such other person," and that there was no reasonable cause to believe the firm's procedures were not being complied with by the portfolio managers.
