Our laboratory's aldosterone normal reference values were 20 150 ng/l and PRA 0.7 2.6 ng/ml/h.
This work has been supported by research funds granted to Marco Viccaro by the University of Catania (FIR 2014 cod. 2F119B and PRA 2016-18 cod. 22722132120) and by EarTherm (Spin-Off Enterprise of the University of Catania).
Three samples (PRB 936-04, PRA 201-05, and PRA 201-17) were diluted twofold serially with HIV negative human pooled plasma and were used to evaluate the antigen detection sensitivity of the enzyme immunoassay (EIA).
Next, the antigen detection sensitivities of the two tests were compared using serial twofold dilutions of three HIV-1 antigen samples (PRB936-04, PRA 201-05, and PRA201-17).
In support of this observation, among recipients of HLA-identical sibling transplants, patients with no PRA had significantly higher 10-year graft survival than patients with PRA >1%, suggesting that non-HLA immunity has an important role in clinical transplantation and chronic graft loss 37.
There was no evidence of primary aldosteronism (aldosterone 8 ng/dl, PRA 4.73 ng/ml/hr, serum K+ 3.7 mmol/l.
Serum aldosterone was 20 ng/dl, PRA <0.2 ng/ml/hr (ARR >100 ng/dl:ng/ml/hr), and urinary aldosterone 20 µg/24 hr (nl 2 20).
While the maternal grandmother (1390-5) was diagnosed with adult-onset hypertension, her aldosterone was normal (16 ng/dl), with non-suppressed PRA (18.92 ng/ml/hr) (Table 2).
At age 51 years, on treatment with 12.5 mg hydrochlorothiazide, his BP was 120/8 0mmHg, with aldosterone 11 ng/dl and PRA 1.2 ng/ml/hr (note that treatment with hydrochlorothiazide increases PRA), with serum K+ 3.8 mmol/l.
Her mother showed normal plasma electrolytes concentration, but elevated PRA (7.5 ng/ml/hr) and aldosterone level (931 pg/ml) were noted.
During an in-person meeting these 10 cases were eventually judged to be 1 case of PRA, 3 cases of ATN and 6 cases of indeterminate.
