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For all 38 evaluable patients at 1 year, responses were CR 84%, PR 1%, and progressive disease 13%.
b Primary lamellae (Pr) (1 g vit.E).
In the 16 resistant patients, 12 PR, 1 mixed response and 3 SD were obtained.
In the 5 patients treated at diagnosis 2 PR, 1 CR and 2 VGPR were observed.
The absorption experiment of phenol red (PR, 1 mM) was performed by the same method.
These screens identified a mutation designated as N on-Expressor of PR 1 (NPR1).
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The time course of PR-1 expression was studied.
The genome of cacao (Theobroma cacao) encodes 14 PR-1 proteins, named TcPR-1a to TcPR-1n.
The PR-1 proteins (pathogenesis-related protein 1) are involved in plant defense mechanisms against various pathogens.
Accordingly, the chemical reduction of NRP1 and thus the induction of NPR1-dependent genes such as PR-1 correlates with the reductive phase of the defence response34.
Surprisingly, the PstAvrB-induced upregulation of PR-1 was significantly muted in both GC6 and GC27 plants compared to wild-type plants (Fig. 2d).
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