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Inhaled NO, 40 ppm, was administered during OLV, and the inhaled gas mixture was monitored for NO and nitrogen dioxide (NO2).
Inorganic arsenic (arsenic, 10 ppm) was administered to mice (~ 8 weeks of age) as sodium arsenite (Fisher Scientific, Waltham, MA) in drinking water for 4 weeks.
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At this time prostaglandin E1 (40 g/kg/min) by continuous infusion and INO (40 ppm) were administered.
Other study by Castilla et al [ 43] reported a reduction of the enzyme Na+, K+-ATPase in brain membranes when high doses of toluene vapour (30,000 ppm) were administered subchronically to rats, but there was an increased Na+, K+-ATPase activity during acute exposure.
2000 ppm dosage of TCA was administered orally to 6 male rats ad libitum during the tests for 52 days consecutively.
Finally, administration of increasing concentrations of genistein during embryonic and postnatal development induced mammary gland hyperplasia in both male and female rats at PND50 when genistein was administered at 250 ppm or higher [ 43].
Study Design: One of the following solutions was administered in the drinking water of CD-1 male mice: (1) 4 ppm HgCl2; (2) 800 ppm ZnCl2; (3) 4 ppm HgCl2+800 ppm ZnCl2; or (4) deionised water; for 12 weeks.
Doxy was administered using chow containing 2000 ppm doxy (Research Diets).
The second dose of immunocastration vaccine was administered 28 d before slaughter, and 5 ppm of ractopamine was added to the diet of half of the pens for each treatment at that time.
After a stable elevated PAP was reached, 4 or 10 ppm NO with or without zaprinast (50 µg) or sildenafil (10 ng) was administered for 3 min and the decrease of PAP was measured.
NaClO was administered to male and female rats, respectively, at doses of 1000 or 500 ppm and 2000 or 1000 ppm for 104 weeks.
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