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Monoclonal antibodies (mAbs) are powerful therapeutics, and their characterization has drawn considerable attention and urgency.
However, employing reversible covalent warheads in drug design has given rise to covalent enzyme inhibitors that serve as powerful therapeutics, as well as molecular probes with exquisite target selectivity.
In contrast to these in vivo and in vitro data, targeting IL-1 has not yet provided powerful therapeutics for the treatment of RA [ 59].
Therefore, molecules that can modify these complex interactions between muscle cells and their environment can be powerful therapeutics for the treatment of DMD.
Herbal medicines have been proved to be powerful therapeutics for treatment of various human sufferings including cancer, arteriosclerosis, ulcer, diabetes, kidney diseases, and liver diseases [ 10].
The challenge to propose new powerful therapeutics for neuropsychiatric disorders, including antidepressants, has raised important questions regarding the efficiency of preclinical approaches currently being used [ 1– 3].
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Over the last three decades, monoclonal antibodies have made a dramatic transformation from scientific tools to powerful human therapeutics.
In this review, we will highlight the early cellular and molecular purinergic cross-talk that participates to ALS etiopathology, with the conviction that better understanding of purinergic dynamics might provide original research perspectives, stimulate alternative disease modelling, and the design and testing of more powerful targeted therapeutics against this relentlessly progressive disorder.
Nonetheless, CiPSCs provide a new tool to study the mechanisms of reprogramming that may lead to more improvements in iPS cell production and safety, and eventually powerful iPS cell therapeutics.
Synthetic siRNAs capable of inducing sequence-specific gene silencing are emerging as a potentially powerful new class of therapeutics.
(11) With the added benefit of the prolonged effects of BoNT/B, 18) this strategy introduces a powerful new class of therapeutics.
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