A latent but powerful substrate-selective disposal process, termed "rapid disposal" (RD), has thus been found in the early post-translational processing of proinsulin.
This wealth and density of mutations in miRNA genes within a single species and between sister species thus provide a powerful substrate to test the processes driving their microevolutionary dynamics.
According to the model, it is predicted that Al3Ti is a more powerful nucleating substrate for Al alloy than TiC, TiB2 and AlB2.
In this study, we found that combining affinity column chromatography using the catalytic domain of Rho-kinase and shotgun LC-MS/MS analysis is powerful for identification of substrates, including known substrates and novel ones, such as DCX, APP and AP180.
Combining this simple method with a conventional method, such as 2D-DIGE, would be more informative and powerful for screening novel substrates of specific kinases and would increase understanding of the phosphorylation network.
Besides their powerful role as energy substrates and precursors of other lipids, FAs are directly involved in cellular signaling pathways and regulation of gene transcription.
Conducting polymer-based cell culture substrates provide a powerful tool to control both chemical and physical stimuli sensed by stem cells.
We show unambiguously that ADP release is the rate limiting step of the reaction pathway and that KanA is at once a substrate and a powerful inhibitor because it interacts with the intermediate E·ADP as well as with the apoenzyme.
This suggests that kinase activation alone is the rate-limiting step for substrate phosphorylation and that in vivo substrate phosphorylation kinetics could be used as a powerful predictor for identifying previously unknown, physiological kinase-substrate relationships.
