"powerful paradigm" is correct and usable in written English.
You can use it to refer to an influential philosophical or theoretical framework, such as a powerful scientific, social, or religious paradigm. For example, "Freud's psychoanalytical paradigm has been a powerful influence in the field of psychology for over a century."
"Search, broadly speaking, is the most powerful paradigm in advertising today," he argued.
Learning by multimodal observation of vision and language offers a potentially powerful paradigm for robot learning.
Model-based reinforcement learning is a powerful paradigm for learning tasks in robotics.
The virtual synchrony model for group communication is a powerful paradigm for building distributed applications.
Model reconstruction provides a powerful paradigm for modeling shapes from samples.
Our results establish a powerful paradigm for identifying protein binding sites and interpreting gene regulatory sequences in eukaryotic genomes.
Quantum information science promises fundamentally new and vastly more powerful paradigms of computation, sensing, and communications.
Such electronic circuits are especially ill-suited for dealing with quantum information – states of a physical system that possess nonclassical correlations and enable vastly more powerful paradigms of computation, communications, and sensing (Preskill2012).
Prediction of acid gases solubilities in ionic liquids (ILs), have recently emerged as promising mediums for refining of natural gas, using powerful paradigms is of great importance from technical and economical point of view.
Regenerative medicine is evolving toward a powerful new paradigm of functional restoration.
Generating clones of mutated cells within a wild-type tissue is a powerful experimental paradigm for elucidating gene function.
