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Inthout and colleagues quantified the error rates for evaluations based on single conventionally powered trials (80% or 90% power) compared to evaluations based on random-effects meta-analyses of a series of smaller trials [ 6].
Postpyloric tube placement is associated with reduced gastric residual volume and reflux, but adequately powered trials are not available to support prevention of aspiration pneumonia.
Rigorous evaluation of constraint-induced movement therapy using well-designed and adequately powered trials is required to evaluate the efficacy of different protocols on different stroke populations and to assess impact on quality of life, cost and patient/carer satisfaction.
Appropriately powered trials using the SPPOST as a screening tool for physiotherapy input are therefore needed to confirm its effectiveness.
There is a need for low risk of bias, comprehensively reported and properly powered trials evaluating the efficacy of generic and specific exercise interventions for injury prevention.
Secondly, only thirty-four patients were included in the study, and larger, higher powered trials are needed to verify the results.
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This trend may be a response to the difficulty of designing adequately-powered trials of interventions used to treat pediatric conditions which are frequently comparatively rare.
Probiotic strategies deserve consideration in future well-powered trials.
Conducting rigorous, adequately-powered trials of nonpharmacological interventions for patients with rare diseases is difficult.
Under-powered trials are considered unethical[ 38]; therefore our sample size calculations are based on conservative estimates and high power.
Both are large, well-powered trials with primary disease-free survival endpoints and secondary overall survival endpoints.
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CEO of Professional Science Editing for Scientists @ prosciediting.com