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Hence, we decided to pursue a fully powered trial, with the main phase (MP) power calculation based on the mean difference in AUDIT scores (the primary outcome) between the two groups at the end of the run-in phase.
This simulation technique can be used to estimate the possible ranges of the ICC values and to help to design an appropriately powered trial.
Utilising the concept of equivalence[15], it was estimated that an adequately powered trial would consist of 25 patients with 95% confidence intervals for a clinically acceptable difference of ±5 mmHg between the gold standard (PAC) and TTE-determined MPAP.
These findings from trials with a high risk of bias demonstrate the need for an adequately powered trial with a low risk of bias to evaluate the efficacy of eccentric hamstring exercises on hamstring injury incidence.
Whether combination therapy proves beneficial in these patients with poor prognosis on standard therapy needs to be addressed by an adequately powered trial with strict monitoring of potentially dangerous adverse effects in this particular subgroup of severely ill patients.
No adequately powered trial has compared these TKIs.
Similar(7)
This trial is strategically designed as a vanguard for a fully-powered trial of women who will be evaluated for breast cancer recurrence and disease-free survival.
A larger, well-powered trial is needed to evaluate the cardioprotective effects of MC-1.
The increase in the incidence of severe hypoglycemia forced the investigators to stop the study, leaving us with under-powered trial results.
This protocol, with some modifications to outcome measures, screening procedures, time span, and inclusion criterion, can be extended to a fully-powered trial.
53 This clearly underlines the need for a well-powered trial to confirm the efficacy of telmisartan for reducing insulin resistance and this is met by the current study.
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