Thus, further investigation is necessary to elucidate these dynamics, both in terms of study design and physiology, perhaps using more precise tools to assess diet or in more powerful studies of different design (e.g. intervention studies adequately powered to test gene treatment interactions).
This study was not designed or powered to test this hypothesis so it would be inappropriate to draw conclusions from this result.
The study was powered to test the primary hypothesis, namely that paracetamol 1,000 mg + caffeine 130 mg would be non-inferior to SUM as regards the proportion of patients within the 4-h post-dose period.
Although gene therapy approaches tested so far have been shown to be safe, none met their primary endpoints in phase II clinical trials designed and powered to test the efficacy of the intervention.
The surprising observation that there was a significant reduction of headache attack frequency in addition to the acute response has to be seen with caution, as this study was designed and powered to test the acute effects on spontaneous cluster headache attacks.
The study was powered to test the primary hypothesis, namely that paracetamol 1,000 mg + caffeine 130 mg (PCF) would be non-inferior to naproxen sodium 550 mg (NAP) as regards the proportion of patients complaining of AEs in the 4-h post-dose period.
The study is sufficiently powered to test the secondary hypotheses.
We are also powered to test the listed secondary outcomes.
The trials were not designed nor powered to test the difference for the secondary outcomes.
The study was not powered to test differences in mean adherence.
The study was powered to test hypotheses other than those tested here.
