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No difference was observed in the haplogroup J frequencies between the centenarians or either matched control group, despite adequate statistical power to detect such a difference.
The relatively small number of cases annually means that, although there appeared to be no change in the serotype distribution of disease in homeless persons in association with the introduction of a pediatric vaccination program, our power to detect such a difference was low.
This sample size provides 80% power to detect such a difference with 95% confidence.
Including the occasional mismatch likely reduces our power to detect such a pattern, not create it.
At least 250 subjects were required to give 90% power to detect such a difference.
First, these RCTs might lack sufficient power to detect such a rare occurrence of AF.
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However, the studies would need to have sufficient power to detect such an interaction.
We estimated our power to detect such an HR as follows.
Using G*Power software (version 3.1.0, Germany) [8], and given this magnitude of effect size, our sample has over 99% power to detect such an effect.
The power to detect such an effect by our method, given our sample size, is greater than 87% for any value of α greater than 0.01.
The reason behind this finding is unknown but may simply be the consequence of insufficient power to detect such an effect, given the small number of women with the MTHFR 677TT genotype (n = 14).
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