Sentence examples for power of variant from inspiring English sources

In the future, the improvement of reference assemblies, bioinformatic tools and sequencing technology will be necessary to improve the power of variant discovery techniques.

Trimming off low-quality tails from reads even worsen the power of variant calling, although it helps align more reads with high error rate in the tail.

A reference-free method that captures all information from the reads can potentially avoid the sequence problems of an error-prone early draft genome and reduce expense from the time and effort required to create one and therefore potentially maximise the power of variant calling.

However, we expect this more precise definition of functional SNP sets will allow a sharp increase in the power of variant set enrichment analyses, and this will allow VSEAMS analyses to interpret functionally defined genetic regions by linking them to end-point phenotypes.

This increased the statistical power of the variant allele likelihood estimation compared with the by-sample approach as information to support a variant allele call comes from all eight rather than just one sample.

In addition, there are many different types of study designs and analytic techniques that have been developed specifically to maximize the power of rare variant association studies (RVASs).

This should increase the accuracy of epidemiological studies, increase the power of causal variant detection and give increased confidence to clinical conclusions taken from sequencing data.

> -wrap-foot> as a first step, we compare the statistical power of the variant calling method based on the Skellam distribution with one based on the Poisson model.

The power of rare variant association methodology is also likely to vary according to the technology used to assay genetic variation.

We demonstrate that power of rare-variant association tests is higher in the Finnish population, especially when variants' phenotypic effects are tightly coupled with fitness effects and therefore reflect a greater contribution of rarer variants.

We show that augmenting sequence data with imputed samples is a practical method for increasing the power of rare-variant studies.