The predictive power of the binding energy weight model appears to be limited as several predicted binding motifs have low theoretical KDs but nevertheless did not exhibit a specific interaction in vitro and vice versa, as several specifically bound motifs have high theoretical KDs (Additional file 7: Table S2).
In order to assess the predictive power of the binding probabilities, we first used them to predict known TF target gene interactions from the Incyte YPD database by using a 5-fold cross-validation approach.
An attractive approach is to incorporate biologically relevant data, such as protein co-occupancy, to improve the power of protein-binding detection.
The reason is that the prediction power of sequence-specific binding and non-specific binding residue on β-sheet structure is worse than that of α-helix and coil.
We introduced a new statistical method to improve the power of detecting protein binding in ChIP data by combining additional biological features.
For the prediction power of particular TF binding feature, there is a difference with that of histone modifications; that is, most transcription factors exhibit important effects to chromatin accessibility).
Moreover, the findings illustrate the power of single-molecule binding and diffusion studies, in concert with activity studies, to reveal the hidden steps in the activation mechanisms of membrane-bound signaling proteins.
The democratic ideal of autonomy leads David Held and others to emphasise the emerging structures of international law that produce a kind of binding power of collective decisions.
Importantly, MeDiChISeq takes advantage of the shape of the binding event itself as a resource for identifying them in an accurate manner; thus by providing a higher power of discrimination between true binding events and artifactual read-count enrichment patterns.
Politics and language: multiculturalists argue that the binding power of the liberal nation state has been eroded from within by value diversity and from without by the arrival of immigrant communities with other loyalties.
