Sentence examples for power linkage from inspiring English sources

As the success of association mapping is reduced by small effect sizes and limited power, linkage studies in laboratory-based model systems are still heavily used.

One approach to increase the power in linkage and association studies is to study small populations with increased linkage disequilibrium and decreased genetic diversity.

Further genetic dissection of this locus is limited by the power of linkage analysis and the mosaic structure of the murine genome, leading to a high degree of linkage disequilibrium in the region of interest [45].

Despite the limited power of linkage analysis to detect QTLs with only 416 DZ twin pairs, we found a region of suggestive linkage on chromosome 3 with an LOD score of 2.65 at D3S2396.

An approach commonly used to increase statistical power in linkage studies is the study of extremely discordant sibling pairs.

Ascertaining consanguineous families with multiple affected children (suggesting recessive inheritance) would theoretically reduce genetic heterogeneity and increase power for linkage.

If imprinting plays a role in the heritable etiology of ASD, the power of linkage analyses to identify susceptibility loci may be improved by accounting for allelic parent-of-origin.

These results may explain the better power of linkage analysis using this "subgroup" strategy.

Admixture mapping has more power than linkage mapping when detecting disease-associated variants with highly differentiated frequency across ancestries.

This process is an important methodological development to increase the power of linkage studies when all individual data elements are not available for all individuals.

The strength of the NAM method is that it combines the power of linkage mapping with the resolution of association mapping.