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To ensure sufficient power in the detection of both isoforms at AS events, we first focused, for each condition of immune stimulation, on genes with an average FPKM > 10, and AS events where each possible alternative intron was supported by at least 30 spliced reads.
If the proportion by background QTLs is large, large residual variance will result in a decreased power in the detection of the current QTL and sometime the QTL can not be identified.
The results (Table 5) show that the estimates for the positions and variances of simulated QTLs are close to their true values, and the power in the detection of QTL is high (e.g., over 80% for the QTLs with a heritability over 2%), especially for QTL-by-QTL interactions.
To conserve power in the detection of putative new colorectal cancer biomarkers, we did not rank CpG sites by p value nor did we use multiplicity correction.
Moreover, all the tests applied have been shown to have similar power in the detection of recent bottlenecks [ 29], so that they are expected to give similar results under a purely demographic scenario.
Group sample sizes of 40 and 40 can achieve 91% power in the detection of a difference of one point for a 10-point VAS scale in a design with six repeated measurements, when the standard deviation is 1.8 points.
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This methodology presumably increased our statistical power, aiding in the detection of variation in overnight adrenal production of cortisol in menstrual cycles with prolonged inter-ovulatory-intervals (IOIs).
This method has been shown to outperform haplogroup-stratified or haplogroup-adjusted association analyses with no loss in power for the detection of true associations.
Solbiati et al. [ 10] evaluated contrast agent-enhanced color and power Doppler US in the detection of residual tumor after RF ablation of 20 colorectal liver metastases.
As a consequence, large samples are needed in order to have sufficient power for the detection of genetic variants implicated in ADHD [ 18, 19].
The differences between T1ρ and T2 in the sensitivity and diagnostic power for the detection of early macromolecular changes in cartilage might have caused the discrepancy between their results and ours.
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