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The limited number of detected epistatic QTL may be misleading because the power to detect them depends more on population size than the power for the detection of main effect QTL.
In our setting (~35 M reads per sample) and at this level of expression (FPKM = 0.5), we expect to find ~15 reads per sample for each kb of the minor transcript, providing high power for the detection of both isoforms.
However, the sample size was large enough to guarantee 80% power for the detection of effects in the range suggested by the extant literature.
Additional simulation studies were performed to test the power for the detection of imprinting effects at different levels.
The discovered salivary biomarkers possess discriminatory power for the detection of breast cancer, with high specificity and sensitivity.
The impact of using convenience controls on the power for the detection of disease related markers needs to be further investigated, especially in recently admixed populations.
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This discussion makes clear that improved estimation of G is a critical issue for the design of training populations, for increased prediction accuracy and for increased power of the detection of marker-trait associations.
At first sight, these results indicate that the study was insufficiently powered for the detection of age effects on valuation scores, especially for the TTOs.
The powers for the detection of an effect when considering the subset of 26 sites or the 19 EGNS alone were slightly lower (data not shown).
While this study is well powered for the detection of small, common effects underpinning the genetic origins of AD, it suffers from several limitations.
The analysis was sufficiently powered for the detection of DMCs, as the three pairwise comparisons yielded 2.26- to 5.02-fold more DMCs (38,008 to 84,183 in pairwise comparisons) than expected by chance (Table 2).
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