In C2C12 cells, its overexpression stimulates mitochondrial activity and potentiates terminal differentiation [10], [11].
After 4 weeks of high-fat diet excised pads with Rorγ−/− cells contained more mature adipocytes than pads with cells from control animals, demonstrating that the absence of RORγ potentiates adipocyte differentiation (Fig 4A, right panel).
Vascular endothelial growth factor receptor 2 is believed to be the major mediator of angiogenesis in human malignancy, as it regulates activation of downstream effector molecules such as phosphoinositide 3-kinase and AKT, and potentiates endothelial differentiation, DNA synthesis and proliferation (Waltenberger et al, 1994; Meyer and Rahimi, 2003).
To determine whether FSH could potentiate osteoclast differentiation in ITAM-adapter deficient mice, we evaluated the effect of FSH during in vitro osteoclastogenesis.
Interestingly, the NLR agonist PGN potentiated the differentiation of monocytes to fibrocytes.
In our study, hypoxia potentiated ESC differentiation towards endo-mesodermal lineage (Fig 1).
Furthermore, in the presence of AIM, the knockdown lentivirus potentiated adipocyte differentiation, evidenced by the increased number of Oil Red O-positive adipocytes.
Similarly p38 MAPK activity can potentiate myogenic differentiation in ERMS cells by enhancing MYOD trans-activation properties.
TLR4 agonist LPS also potentiated the differentiation of monocytes to fibrocytes, though the increase was not significant by either ANOVA or t-test.
Knockdown of LRP6 in 3T3-L1 cells downregulated β-catenin/T-cell factor (TCF) transcriptional activity and dramatically potentiated the differentiation of the cells into mature adipocytes.
