This 'Type II' assay, in which the antibiotic to which the bacteria are resistant is added uniformly to the agar, therefore exposes potentiated, interaction-mediated, selection for and against resistance.
As depicted in Fig. 5a, b, VEGF-A activity was inhibited by the combined regimen showing the best effect with synergistic interaction on MCF-7 and potentiating interaction on T47D.
Embryonic fibroblasts cultured from CCN2-deficient animals show reduced signaling responses to adhesion and impaired stress fiber formation on fibronectin, suggesting that a physiological role of CCN2 is to potentiate interaction of cells with matrix [ 5].
Additionally, isoprenoids such as quinones, chlorophyll, bacteriochlorophyll, and some cellular proteins are tethered to a polyisoprenoid chain to direct localization to membranes or to potentiate interactions with other biomolecules (Nowicka and Kruk, 2010; Schafer and Rine, 1992).
The mechanism depends on the generation of 'NMDA spikes' within the thinner, more distal ramifications of basal and apical dendrites (Larkum et al. 2009; Schiller et al. 2000), whose capacity to initiate axonal spikes is potentiated through interaction with the backpropagation of action potentials from the axon hillock through to the dendritic tree.
On the other hand, the results show also that E. cannabinum can increase aneugenic effects of the environmental pollutant BPA, drawing attention to the possibility that BPA adverse effects may be potentiated by interaction with other chemicals.
Moreover, agrin potentiates the interaction of APP with LRP4.
Since PYL8-PP2C bisdindependentpendent of ABA, PYL8 may be responsible for constitutive ABA signaling that is independent of ABA itself or ABA may be required to fully potentiate PYL8-PP2C interaction.
There is now a vast literature describing potentiating interactions between intercellular messenger molecules.
However, I am not aware that anyone has proposed a Theory on Potentiating Interactions at the molecular level.
In the words of the Nobel laureate Sir James Black: " Physiological systems that are organized by chemical convergence based on potentiating interactions will need pharmacological convergence to manage them effectively.
