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When adoptively transferred into lymphopenic hosts, either individually or combined, both Th1 and Th17 cells per se were capable of inducing EAE, but combinations of Th1 and Th17 cells displayed a potentiated effect.
Oxidative stress is therefore not likely to be involved in the potentiated effect of 5FU after HBO.
In the case of two drugs this could lead to a potentiated effect of the combination of agents.
Furthermore, it suggests that the potentiated effect observed for RM is not dependent on the presence of retinyl ester-containing lipid droplets.
The potentiated effect of SA treatment on furanocoumarin secretion and subsequent Pep13 addition has been shown in previous publications [ 8, 10, 36].
However, the combined drug treatment resulted in potentiated effect (85.42% Annexin V/PI positive cells), suggesting that everolimus enhanced sorafenib-induced apoptosis of MPM cells.
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This may be analogous to the modestly potentiated effects of exogenous VDR on 1,25(OH 2D3-mediated increase OH 2D3-mediatede 2E), as CaCo2 cells are known to up-regulate VDR upon confluence/dincreaseiatiof [31].
In addition, potentiated effects (effects of Pb plus stress but showing no changes produced by either alone) were observed more frequently in females.
Regardless, the DE-induced potentiated effects at the higher doses of dobutamine reflect a shift from the normal function of the heart.
Moreover, the interactive effects of Pb and stress, and particularly the potentiated effects of Pb plus stress, raise questions about whether current risk assessment strategies sufficiently consider the potential for modulation of toxicity that can accrue from intercurrent risk factors.
This second finding shows that previous potentiated effects of fornix transection after extensive white matter disconnections of temporal cortex (Gaffan et al. 2001) are almost entirely due to the prior deafferentation of cholinergic input of temporal cortex.
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