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The Sch B product caused a 32% increase in cellular glutathione level and the γ-schisandrin-enriched product a 26% increase, indicating a potentially more efficacious pharmaceutical preparation.
Since about half of the patients treated with neoadjuvant chemotherapy will not respond [ 7], an early predictor of response would avoid futile therapy and allow patients to pursue other, potentially more efficacious treatments.
Our study indicates that a unique four-drug regimen (LOAD) is potentially more efficacious than the standard of care (LAC) for the treatment of HP in a treatment-naive population.
Recently, third-generation aromatase inhibitors, which block the conversion of androgens to estrogens, have been shown to be potentially more efficacious than tamoxifen [ 15], but recently reported side effects, including bone loss, joint pain, and cardiac events, have caused concern [ 16].
The patient was informed that the first dose level was lower than that which was expected to be selected as the MTD, and being concerned about not receiving a potentially more efficacious dose, she asked if she could delay entry to the study until a later time when higher doses might be available.
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This could spare patients toxicity of non-efficacious therapy, and allow revision to a potentially more effective regimen in patients who are destined to respond poorly to the initial treatment.
These antibody drug conjugates (ADCs) are being developed in the quest for potentially more clinically efficacious drugs and to confer higher tumor selectivity.
Indeed, a role for enzalutamide in all patients with metastatic CRPC is hinted at by the data from the Phase I/II studies, where enzalutamide appeared efficacious (and potentially even more efficacious) in chemotherapy-naïve patients.
Although it is generally assumed that paclitaxel and docetaxel share a similar mechanism of action and, therefore, target a similar tumor population, this might not be the case as docetaxel could potentially be more efficacious in highly proliferative tumors.
Treatment strategies dependent on the integrity of T-cell function, such as vaccination approaches (Morse, 2000), could potentially be more efficacious if initiated before radio-chemotherapy, or following recovery of T-cell function after cessation of therapy.
Despite of the limitations of this preliminary case study such as the very small sample population and relatively short followup of 9 12 months, our initial results nevertheless suggest that bioengineered RHCIII-MPC implants may potentially be more efficacious alternatives to donor tissues in repairing corneas with severe pathologies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com